The gut microbiota directs vitamin A flux to regulate intestinal T cell development
Tarun Srinivasan, Chaitanya Dende, Kelly A. Ruhn, Stefanie L. Moye, Ann Johnson, Cassie L. Behrendt, Brian Hassell, Gonçalo Vale, Jiwoong Kim, Jake N. Lichterman, Chaoying Liang, Carlos Arana, Prithvi Raj, Xiaowei Zhan, Jeffrey G. McDonald, , Lora V. Hooper
This paper shows the gut microbiota regulates intestinal T cell development by directing vitamin A flux through a sequential pathway involving epithelial, myeloid, and T cells.
Cell Host & Microbe · Jun 17, 2026Peer-reviewedImmunology