Lora V. Hooper

Intrinsic timekeeping in Escherichia coli

This study shows Escherichia coli has an intrinsic timekeeping system that anticipates daily temperature cycles through rhythmic curli plaque formation.

Salmonella lipopolysaccharide stimulates uptake of long-chain fatty acids in the small intestine

This study shows Salmonella LPS enhances fatty acid uptake in the mouse intestine via CD36 and myeloid TLR4, linking microbial sensing to lipid absorption and host defense.

The gut microbiota directs vitamin A flux to regulate intestinal T cell development

This paper shows the gut microbiota regulates intestinal T cell development by directing vitamin A flux through a sequential pathway involving epithelial, myeloid, and T cells.

Microbiota-derived short-chain fatty acids mediate Candida albicans gastrointestinal colonization resistance

This study identifies microbiota-derived short-chain fatty acids as key mediators of Candida albicans colonization resistance in the gut.

B3GNT7 regulates mucin glycosylation and protects against colitis and infection

This study shows B3GNT7 regulates colonic mucus glycosylation, protects against colitis and infection, and has a distinct function from other B3GNT family members.

Epithelial sensing of vitamin A shapes intestinal antimicrobial defense

This study shows dietary vitamin A enhances intestinal antimicrobial defenses by promoting REG3 lectin and defensin expression through retinoic acid receptor signaling.

A single-cell atlas of intestinal immune cells across the day-night cycle reveals dynamic populations

The paper constructs a single-cell atlas of mouse intestinal immune cells across the day-night cycle, revealing circadian dynamics in gene expression and cell populations.

Timing of immune checkpoint blockade shapes anti-tumor immunity via a clock-dependent chemokine axis

This study shows that the time of day affects cancer immunotherapy efficacy through a circadian clock-dependent chemokine axis in mice.

Translational control of innate barrier defense by the gut microbiota

The gut microbiota enhances translation of innate barrier defense proteins through HDAC5-mediated activation of mTORC1 signaling.

A Short Plus Long-Amplicon Based Sequencing Approach Improves Genomic Coverage and Variant Detection In the SARS-CoV-2 Genome

The paper improves SARS-CoV-2 genomic coverage and variant detection by combining short (ARTIC) and long amplicon sequencing approaches.