Author

Xiaowei Zhan

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Bioinformatics· 2 Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

Jiwoong KimiD· 4 shared Guanghua XiaoiD· 3 shared Yang Xie· 3 shared Andrew Young KohiD· 2 shared Cassie L. BehrendtiD· 2 shared Lora V. HooperiD· 2 shared Ruheng WangiD· 2 shared Aidan C. Morrill· 1 shared

Activity by Year

2020-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersImmunology

Jiwoong KimORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

SpatialOmicsLab: an integrated research environment for AI co-scientists in spatial transcriptomics

Yi Jiang, Xiaowei Zhan, Peiran Quan, Ruheng Wang, Fangjiang Wu, Junhui Mi, Jia Yao, Bo Yao, Guanghua Xiao, Wenqi Shi, Yang Xie

SpatialOmicsLab provides an integrated environment with AI tools for spatial transcriptomics analysis, outperforming expert workflows in multiple tasks.

bioRxiv · Oct 8, 2026 · PreprintBioinformatics

The gut microbiota directs vitamin A flux to regulate intestinal T cell development

Tarun Srinivasan, Chaitanya Dende, Kelly A. Ruhn, Stefanie L. Moye, Ann Johnson, Cassie L. Behrendt, Brian Hassell, Gonçalo Vale, Jiwoong Kim, Jake N. Lichterman, Chaoying Liang, Carlos Arana, Prithvi Raj, Xiaowei Zhan, Jeffrey G. McDonald, , Lora V. Hooper

This paper shows the gut microbiota regulates intestinal T cell development by directing vitamin A flux through a sequential pathway involving epithelial, myeloid, and T cells.

Cell Host & Microbe · Jun 17, 2026Peer-reviewedImmunology

Microbiota-derived short-chain fatty acids mediate Candida albicans gastrointestinal colonization resistance

Animesh Anand Mishra, Suzette N. Palmer, Christina M. Zarek, Laura A. Coughlin, Nicole A. Poulides, Jana Dakour, Rebecca Suet-Yan Chiu, Parastoo Sabaeifard, Wenling Li, Aidan C. Morrill, Jiwoong Kim, Shuheng Gan, Cassie L. Behrendt, Monika I. Antczak, Xiaowei Zhan, , Andrew Young Koh

This study identifies microbiota-derived short-chain fatty acids as key mediators of Candida albicans colonization resistance in the gut.

Cell Host & Microbe · Jun 4, 2026Peer-reviewedMicrobiology

Attention Guided Mechanism Interpretable Drug-Gene Interaction (MIDI) Modeling for Cancer Drug Response Prediction and Target Effect Explanation

Tingyi Wanyan, Ling Cai, Deepak Nijhawan, Bruce A. Posner, Jiwoong Kim, Rongqing Yuan, Ruheng Wang, Jingwei Huang, Shengjie Yang, Prema Latha Mallipeddi, Tao Wang, Xiaowei Zhan, Guanghua Xiao, Yang Xie

This paper introduces MIDI, a model that predicts cancer drug response and explains drug-target interactions using an attention mechanism, outperforming existing methods in prediction and interpretability.

bioRxiv · Mar 31, 2025 · PreprintCancer Biology

The immune vulnerability landscape of the 2019 Novel Coronavirus, SARS-CoV-2

James Zhu, Jiwoong Kim, Xue Xiao, Yunguan Wang, Danni Luo, Shuang Jiang, Ran Chen, Lin Xu, He Zhang, Lenny Moise, Andres H. Gutierrez, Anne S. De Groot, Guanghua Xiao, John W. Schoggins, Xiaowei Zhan, , Yang Xie

The paper predicts T cell and B cell immunogenic epitopes of SARS-CoV-2 using genomic data and compares them with SARS-CoV and MERS-CoV to identify immune vulnerability patterns.

bioRxiv · Feb 8, 2020 · PreprintBioinformatics