Nascent transcription profiling identifies H3K36 methylation as a custodian of the somatic transcriptome
Hina Sultana, Vasudha Vandadi, Harmony R. Salzler, Apoorva Baluapuri, Darshan Ponkiya, Alexis K Hirth, Grace C Vernesoni, Seth Raphael Goldman, Karen Adelman, A. Gregory Matera
The paper identifies H3K36 methylation as critical for maintaining transcriptome fidelity in metazoans by suppressing aberrant initiation in heterochromatin.
bioRxiv · Oct 28, 2026 · PreprintGenetics