Harmony R. Salzler

Nascent transcription profiling identifies H3K36 methylation as a custodian of the somatic transcriptome

The paper identifies H3K36 methylation as critical for maintaining transcriptome fidelity in metazoans by suppressing aberrant initiation in heterochromatin.

Set2 and H3K36 regulate the Drosophila male X chromosome in a context-specific manner, independent from MSL complex spreading

The paper investigates the role of Set2 and H3K36 in Drosophila dosage compensation, finding that their effects are context-dependent and not directly linked to MSL complex recruitment.

Lysine-36 of Drosophila histone H3.3 supports adult longevity

This study shows that mutating lysine-36 of Drosophila histone H3.3 reduces adult lifespan and disrupts genomic and transcriptomic stability.

Reduced histone gene copy number disrupts Drosophila Polycomb function

The paper shows that reduced canonical histone gene copy number in Drosophila disrupts Polycomb function, leading to developmental defects and ectopic sex combs.

Distinct roles for canonical and variant histone H3 lysine 36 in Polycomb silencing

The paper shows that H3.2 and H3.3 K36 residues have distinct roles in maintaining Polycomb silencing of Hox genes through different mechanisms, enabling development.

Mutations in Drosophila tRNA processing factors cause phenotypes similar to Pontocerebellar Hypoplasia

This study shows that mutations in Drosophila tRNA processing factors cause phenotypes similar to human Pontocerebellar Hypoplasia, including reduced brain size and motor dysfunction.