Acoziborole resistance associated mutations in trypanosome CPSF3
Melanie C. Ridgway, Markéta Novotná, César Mendoza-Martínez, Michele Tinti, Simone Altmann, Graeme M. Sloan, David Horn
The paper identifies mutations in trypanosome CPSF3 that confer resistance to acoziborole, a drug targeting RNA processing, and explains the molecular mechanism of resistance through computational modeling.
bioRxiv · Nov 26, 2025 · PreprintMicrobiology