Author
University of DundeeORCID 0000-0003-3439-9809Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Simone Altmann, César Mendoza-Martínez, Melanie C. Ridgway…·David Horn
The paper uses MOT-library profiling to assess all possible mutations at a drug binding site and predicts resistance mechanisms through computational modeling.
Melanie C. Ridgway, Markéta Novotná, César Mendoza-Martínez…·David Horn
The paper identifies mutations in trypanosome CPSF3 that confer resistance to acoziborole, a drug targeting RNA processing, and explains the molecular mechanism of resistance through computational modeling.
Lesley-Anne Pearson, Alain‐Pierre Petit, César Mendoza-Martínez…·David W. Gray
This study characterizes small molecule inhibitors of the HsRNMT-RAM complex, showing competitive binding and uncompetitive inhibition of RNA cap methylation.