Markéta Novotná

This paper identifies mutations in the gamma subunit of the mitochondrial ATP synthase in Trypanosoma brucei that lead to kinetoplast loss and drug resistance.

The paper identifies mutations in trypanosome CPSF3 that confer resistance to acoziborole, a drug targeting RNA processing, and explains the molecular mechanism of resistance through computational modeling.

The paper shows that specific histone H4 lysine mutations disrupt polycistronic gene expression in trypanosomes by altering promoter-associated chromatin structure.