Melanie C. Ridgway

The paper uses MOT-library profiling to assess all possible mutations at a drug binding site and predicts resistance mechanisms through computational modeling.

This paper identifies mutations in the gamma subunit of the mitochondrial ATP synthase in Trypanosoma brucei that lead to kinetoplast loss and drug resistance.

The paper identifies mutations in trypanosome CPSF3 that confer resistance to acoziborole, a drug targeting RNA processing, and explains the molecular mechanism of resistance through computational modeling.