Reprogramming insulin receptor activation with a de novo agonist to overcome severe insulin resistance
Albert Hung, Xinru Wang, Michael Gao, Michelle Ng, Denys Oliinyk, Riley R. Weaver, Elisabeth Zollbrecht, Sarah Caixeta Cardoso, Gregory Sebastien Ronel, Chloe A Paolucci, Jianxiang Ye, Qing Fan, Elizabeth M. Rhea, Matthias Mann, David A. Baker, , Eunhee Choi
This study develops a de novo insulin receptor agonist, RF-409, which effectively treats severe insulin resistance in a mouse model by activating a mutant receptor and improving glucose homeostasis.
bioRxiv · May 7, 2026 · PreprintPharmacology & Toxicology