Author

Riley R. Weaver

VA Puget Sound Health Care SystemORCID 0000-0002-2555-8065Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Albert HungiD· 1 shared Amanda J. L. RidleyiD· 1 shared Anna L. GrayiD· 1 shared Chloe A PaolucciiD· 1 shared David A. BakeriD· 1 shared Denys OliinykiD· 1 shared Domenico AcciliiD· 1 shared Douglas P. DyeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPharmacology & Toxicology

Albert HungORCID

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2 papers

Recent·Most cited

Reprogramming insulin receptor activation with a de novo agonist to overcome severe insulin resistance

Albert Hung, Xinru Wang, Michael Gao, Michelle Ng, Denys Oliinyk, Riley R. Weaver, Elisabeth Zollbrecht, Sarah Caixeta Cardoso, Gregory Sebastien Ronel, Chloe A Paolucci, Jianxiang Ye, Qing Fan, Elizabeth M. Rhea, Matthias Mann, David A. Baker, , Eunhee Choi

This study develops a de novo insulin receptor agonist, RF-409, which effectively treats severe insulin resistance in a mouse model by activating a mutant receptor and improving glucose homeostasis.

bioRxiv · May 7, 2026 · PreprintPharmacology & Toxicology

Heparan sulfate glycosaminoglycans mediate CXCL4 (PF4) transport across the blood-brain barrier and effects on neurogenesis

Riley R. Weaver, Anna L. Gray, Saudina Mateus-Gomes, Amanda J. L. Ridley, Sean Patrick Giblin, Holly L. Birchenough, Francis C. Peterson, K. Lowe, Yui Matsubara, Iashia Z. Mulholland, Ingo Schießl, Thomas A. Jowitt, James Edward Pease, William A. Banks, Réjane Rua, , Douglas P. Dyer

This study shows CXCL4 enters the brain via GAG-binding to BBB proteoglycans and promotes neurogenesis through GAG-mediated oligomerization.

bioRxiv · Apr 23, 2025 · PreprintNeuroscience