Mesoscale landscaping of the TRIM protein family reveals a novel human condensatopathy
Hari Singh, Vineeta Sharma, Jik Nijssen, Andrei Pozniakovsky, Alexander Rubin, Lorrin Liang, David A. Ball, Sunwoo Hong, Victoria C. Gauntner, Guanghao Yu, Arathi Ranga, David J. Salant, Friedhelm Hildebrandt, Anthony A. Hyman, Amar J. Majmundar
This study investigates mesoscale organization of TRIM proteins, finding that TRIM8 truncations cause condensatopathy by disrupting condensation and signaling pathways.
bioRxiv · Jan 2, 2025 · PreprintCell Biology