Hydrogel confinement enables subcutaneous delivery of vesicant antibody-drug conjugates
Guillaume Jacquot, Capucine Hervy, Elies Belarouci, Adeline Gasser, Chawin Hoernel, Olga Traissard, María Gutiérrez‐Blanco, Julien Draussin, Stéphane Erb, Susana Brun, Lyne Fellmann, Joris Mallard, Elyse Hucteau, Pierre Coliat, Stéphane Bernhard, , Alexandre Detappe
This paper develops a hydrogel that enables subcutaneous delivery of vesicant antibody-drug conjugates by confining them in a depot, reducing tissue damage while maintaining antitumor efficacy.
bioRxiv · May 27, 2026 · PreprintCancer Biology