Alexandre Detappe

This paper develops a hydrogel that enables subcutaneous delivery of vesicant antibody-drug conjugates by confining them in a depot, reducing tissue damage while maintaining antitumor efficacy.

This study evaluates the effects of nanomaterials on human immune cells, finding that PLGA NPs enhance NK cell function while Si-Gd NPs impair T cell activation.

This paper develops a hydrogel platform for subcutaneous delivery of trastuzumab, achieving sustained release over 3 days in vitro and in vivo.

This paper demonstrates that combining radiation with gold nanoparticles enhances tumor vascular permeability and improves nanodrug delivery in pancreatic cancer.