Sébastien Harlepp

This paper develops a hydrogel that enables subcutaneous delivery of vesicant antibody-drug conjugates by confining them in a depot, reducing tissue damage while maintaining antitumor efficacy.

This study shows that tumor cell viscosity affects their ability to circulate and extravasate, influencing metastasis.

This study evaluates the effects of nanomaterials on human immune cells, finding that PLGA NPs enhance NK cell function while Si-Gd NPs impair T cell activation.

This paper develops a hydrogel platform for subcutaneous delivery of trastuzumab, achieving sustained release over 3 days in vitro and in vivo.

This study evaluates IO STMS nanocomposites in a zebrafish metastasis model, showing they inhibit metastatic outgrowth regardless of drug loading and improve embryo survival with increased HSA coating.