Vincent Mittelheisser

This study shows that therapeutic poxviruses induce the secretion of immunostimulating and anti-tumoral extracellular vesicles, which can reduce tumor growth in mice.

This study shows that tumor cell viscosity affects their ability to circulate and extravasate, influencing metastasis.

This study shows that depleting all platelet integrins in mice increases bleeding time, impairs arterial thrombosis, and reduces tumor growth and metastasis.

This study evaluates the effects of nanomaterials on human immune cells, finding that PLGA NPs enhance NK cell function while Si-Gd NPs impair T cell activation.

This paper develops a hydrogel platform for subcutaneous delivery of trastuzumab, achieving sustained release over 3 days in vitro and in vivo.

This study identifies CD24 as a regulator of tumor cell-platelet interactions that enhance metastatic potential and suggests it as a druggable target.

This study evaluates IO STMS nanocomposites in a zebrafish metastasis model, showing they inhibit metastatic outgrowth regardless of drug loading and improve embryo survival with increased HSA coating.

This paper develops a method to functionalize lipid nanoemulsions with antibodies for targeted cancer therapy using a cholesterol anchor and biotin-neutravidin coupling.