Olivier Lefèbvre

Cell viscosity influences hematogenous dissemination and metastatic extravasation of tumor cells

This study shows that tumor cell viscosity affects their ability to circulate and extravasate, influencing metastasis.

Selective targeting of RalA with intrabodies impairs Triple Negative Breast Cancer metastasis

This paper develops RalA-specific intrabodies that inhibit mitochondrial fission and extracellular vesicle secretion, reducing metastasis in a TNBC mouse model.

Depletion of all platelet integrins impacts hemostasis, thrombosis and tumor metastasis

This study shows that depleting all platelet integrins in mice increases bleeding time, impairs arterial thrombosis, and reduces tumor growth and metastasis.

Nanomaterials trigger functional responses in primary human immune cells

This study evaluates the effects of nanomaterials on human immune cells, finding that PLGA NPs enhance NK cell function while Si-Gd NPs impair T cell activation.

Reinforced polymer-nanoparticle hydrogels for subcutaneous and sustained delivery of trastuzumab

This paper develops a hydrogel platform for subcutaneous delivery of trastuzumab, achieving sustained release over 3 days in vitro and in vivo.

Tumoral CD24 tunes platelets binding and pro-metastatic functions

This study identifies CD24 as a regulator of tumor cell-platelet interactions that enhance metastatic potential and suggests it as a druggable target.

Serum albumin coated stellate mesoporous silica nanocomposites inhibit metastatic outgrowth in zebrafish embryos

This study evaluates IO STMS nanocomposites in a zebrafish metastasis model, showing they inhibit metastatic outgrowth regardless of drug loading and improve embryo survival with increased HSA coating.

Functionalization of lipid nanoemulsions with humanized antibodies using plug-and-play cholesterol anchor for targeting cancer cells

This paper develops a method to functionalize lipid nanoemulsions with antibodies for targeted cancer therapy using a cholesterol anchor and biotin-neutravidin coupling.

Endothelial calcium firing mediates extravasation of metastatic tumor cells.

This study identifies endothelial calcium signaling as a key driver of tumor cell extravasation through mechanistic and imaging analyses in zebrafish embryos.