Jacky G. Goetz

This study shows that therapeutic poxviruses induce the secretion of immunostimulating and anti-tumoral extracellular vesicles, which can reduce tumor growth in mice.

The paper introduces a semi-automated image analysis pipeline to quantify lysosome positioning in melanoma cells using ImageJ and CellProfiler.

This study uses 3D invasion models of RCC cell lines to predict their metastatic potential in vivo, showing that 3D models better reflect in vivo behavior than 2D assays.

This study shows that tumor cell viscosity affects their ability to circulate and extravasate, influencing metastasis.

This paper develops RalA-specific intrabodies that inhibit mitochondrial fission and extracellular vesicle secretion, reducing metastasis in a TNBC mouse model.

This study shows that depleting all platelet integrins in mice increases bleeding time, impairs arterial thrombosis, and reduces tumor growth and metastasis.

The paper identifies ER-associated translation machinery in invadosomes using Tks5 interactome analysis, revealing its role in invadosome formation and function.

This study evaluates the effects of nanomaterials on human immune cells, finding that PLGA NPs enhance NK cell function while Si-Gd NPs impair T cell activation.

This paper develops a hydrogel platform for subcutaneous delivery of trastuzumab, achieving sustained release over 3 days in vitro and in vivo.

This study identifies CD24 as a regulator of tumor cell-platelet interactions that enhance metastatic potential and suggests it as a druggable target.

This study evaluates IO STMS nanocomposites in a zebrafish metastasis model, showing they inhibit metastatic outgrowth regardless of drug loading and improve embryo survival with increased HSA coating.

This paper develops a method to functionalize lipid nanoemulsions with antibodies for targeted cancer therapy using a cholesterol anchor and biotin-neutravidin coupling.

This study identifies endothelial calcium signaling as a key driver of tumor cell extravasation through mechanistic and imaging analyses in zebrafish embryos.

This paper identifies a three-dimensional extracellular matrix cage formed by laminin and collagen IV that anchors megakaryocytes in the bone marrow and regulates their maturation and intravasation.

This study shows mechanical stress increases EV release from cancer cells via caveolin-1, leading to more tumorigenic EVs that promote metastasis.

This study shows Ral GTPases regulate exosome biogenesis and organ colonization, promoting metastasis through MCAM/CD146 modulation in breast cancer.