Author

Guillaume Leclerc

MIT Computer Science and Artificial Intelligence Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Agnese GraziosiiD· 1 shared Aine Ni Scannail· 1 shared Aleksander MądryiD· 1 shared Andrea SpitaleriiD· 1 shared Carles A. BoixiD· 1 shared Ching-Chi Chiu· 1 shared Chung Jong Yu· 1 shared Colin Staab· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Agnese GraziosiORCID

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2 papers

Recent·Most cited

ABCA7 Loss-of-Function Variants Impact Phosphatidylcholine Metabolism in the Human Brain

Djuna Katrina von Maydell, Shannon Wright, Ping‐Chieh Pao, Colin Staab, Oisín King, Andrea Spitaleri, Julia Maeve Bonner, Liwang Liu, Chung Jong Yu, Ching-Chi Chiu, Daniel Leible, Aine Ni Scannail, Mingpei Li, Carles A. Boix, Hansruedi Mathys, , Li‐Huei Tsai

This study identifies ABCA7 loss-of-function variants' impact on phosphatidylcholine metabolism in human neurons and shows CDP-choline can reverse these effects.

bioRxiv · Sep 5, 2023 · PreprintNeuroscience

Model metamers illuminate divergences between biological and artificial neural networks

Jenelle Feather, Guillaume Leclerc, Aleksander Mądry, Josh H. McDermott

The paper generates model metamers to compare invariances in neural networks and humans, finding discrepancies and proposing a new benchmark for model assessment.

Nature Neuroscience · Jan 1, 2022Peer-reviewedNeuroscience