Author

Liwang Liu

Massachusetts Institute of Technology

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Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Li‐Huei TsaiiD· 5 shared Aine Ni Scannail· 3 shared Colin Staab· 3 shared M KellisiD· 3 shared Noelle Leary· 3 shared Djuna Katrina von MaydelliD· 2 shared George Samaan· 2 shared Gwyneth WelchiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

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10 top collaborators · 45 mutual co-author links

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5 shared papersNeuroscience

Li‐Huei TsaiORCID

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5 papers

Recent·Most cited

DNA double-strand break signaling induces aberrant neuronal activity

Ping‐Chieh Pao, Liwang Liu, Lauren Ashley Watson, Audrey Lee, Alexander Seguin, Daiyun Dong, Samaa Rasheed, Colin Staab, Oisín King, Ute Geigenmüller, Jay Penney, Fan Gao, Abdurrahman Muhtaseb, Ravikiran M. Raju, Li‐Huei Tsai

This study shows that p53 activation via DNA damage response causes aberrant neuronal activity in neurodegenerative diseases, and inhibiting p53 reduces this activity in a human iPSC model.

bioRxiv · May 13, 2026 · PreprintNeuroscience

Engineered 3D Immuno-Glial-Neurovascular Human miBrain Model

Alice E. Stanton, Adele Bubnys, Emre Agbas, Benjamin T. James, Dong Shin Park, Alan Y. L. Jiang, Rebecca L. Pinals, Liwang Liu, Nhat Truong, Anjanet R. Loon, Colin Staab, Oyku Cerit, Hsin-Lan Wen, David V. Mankus, Margaret E. Bisher, , Li‐Huei Tsai

The paper constructs a 3D human brain model integrating multiple cell types to study Alzheimer's Disease mechanisms linked to APOE4.

Proceedings of the National Academy of Sciences · Oct 17, 2025Peer-reviewedNeuroscience

Compensatory Plasticity Defines a Vulnerable Neuronal State in Alzheimers Disease with Psychosis

Matheus B. Victor, Na Sun, Kyriaki Galani, Noelle Leary, Yosuke Tanigawa, Aine Ni Scannail, Li‐Lun Ho, Shaniah Prosper, Liwang Liu, Julia Kofler, Robert A. Sweet, Li‐Huei Tsai, M Kellis

The paper identifies transcriptional changes in upper-layer cortical pyramidal neurons in Alzheimer's disease with psychosis, linking them to network dysfunction and vulnerability.

bioRxiv · Apr 30, 2025 · PreprintNeuroscience

ABCA7 Loss-of-Function Variants Impact Phosphatidylcholine Metabolism in the Human Brain

Djuna Katrina von Maydell, Shannon Wright, Ping‐Chieh Pao, Colin Staab, Oisín King, Andrea Spitaleri, Julia Maeve Bonner, Liwang Liu, Chung Jong Yu, Ching-Chi Chiu, Daniel Leible, Aine Ni Scannail, Mingpei Li, Carles A. Boix, Hansruedi Mathys, , Li‐Huei Tsai

This study identifies ABCA7 loss-of-function variants' impact on phosphatidylcholine metabolism in human neurons and shows CDP-choline can reverse these effects.

bioRxiv · Sep 5, 2023 · PreprintNeuroscience

Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity

Matheus B. Victor, Noelle Leary, Xochitl Luna, Hiruy S. Meharena, Aine Ni Scannail, P. Lorenzo Bozzelli, George Samaan, Mitchell H. Murdock, Djuna Katrina von Maydell, Audrey H. Effenberger, Oyku Cerit, Hsin-Lan Wen, Liwang Liu, Gwyneth Welch, Julia Maeve Bonner, Li‐Huei Tsai

This study shows that APOE4 in microglia causes lipid accumulation, impairing their ability to monitor neuronal activity and leading to disrupted neuronal network function.

Cell stem cell · Aug 1, 2022Peer-reviewedNeuroscience