Guoqing Hu

Deterministic DNA-first discovery reveals recurrent genomic architectures

The paper introduces a DNA-first framework to detect genomic architectures by analyzing raw DNA sequences, identifying potential RNA-to-DNA systems without prior protein knowledge.

Primitive GLMY Homology: An Algebraic Topology Approach for the Quantitative Characterization of Graph Pangenomes toward Population Genetic Analysis

This paper introduces Primitive GLMY Homology to quantitatively analyze graph pangenomes and applies it to population genetic analysis in yeast.

Tunable Rigid Spikes on Virus-Like Porous Silica Enable Mechanistically Controlled Nanovaccine Platforms

This paper designs tunable, rigid spike architectures on virus-like porous silica nanoparticles to enhance antigen delivery and immune response, showing improved vaccine efficacy compared to traditional adjuvants.

Generation of a novel constitutive smooth muscle cell-specific Myh11-driven Cre mouse model

The paper develops a new Myh11-driven Cre mouse model for precise SMC-specific gene manipulation, avoiding issues of off-target activity and variable integration seen in existing models.

TEAD1 is crucial for developmental myelination, Remak bundles and functional regeneration of peripheral nerves

This study shows TEAD1 is essential for Schwann cell myelination, regeneration, and Remak bundle formation through mechanisms involving proliferation control and cholesterol biosynthesis.

Discovery of an evolutionarily conserved smooth muscle cell-specific lncRNA CARMN

The paper identifies CARMN as an evolutionarily conserved, smooth muscle cell-specific lncRNA, showing its down-regulation in vascular diseases and functional importance in maintaining the contractile phenotype of vascular smooth muscle cells.