ER stress-mediated BK dysfunction in the DRG underlies pain in a model of multiple sclerosis
Muhammad Saad Yousuf, Samira Samtleben, Shawn M. Lamothe, Timothy N. Friedman, Ana Catuneanu, Kevin C. Thorburn, Mansi Desai, Gustavo Tenorio, Geert J. Schenk, Klaus Ballanyi, Harley T. Kurata, Thomas Simmen, Bradley J. Kerr
This study shows that ER stress in DRG neurons contributes to pain in MS and that ER stress modulators can reduce pain hypersensitivity in an EAE model.
bioRxiv · Jan 22, 2020 · PreprintNeuroscience