Shawn M. Lamothe

This study identifies Slc7a5 and LMAN2 as regulators of Kv1.2 channel gating, showing they compete for interaction with the voltage sensor, leading to complex voltage-dependent behavior.

This study identifies LMAN2 as a regulatory protein that modulates redox-sensitive gating of Kv1.2 channels by altering activation kinetics and redox sensitivity.

This study shows that Slc7a5 regulates Kv1.1 channels similarly to Kv1.2, with sensitivity controlled by voltage-sensing domain exchange.

This study shows that ER stress in DRG neurons contributes to pain in MS and that ER stress modulators can reduce pain hypersensitivity in an EAE model.