Harley T. Kurata

Pharmacological profiling of brain activity in zebrafish

This study develops an in vivo zebrafish screening assay to identify drugs that suppress convulsant-induced neuronal hyperexcitability, finding that Kv7 channel activators are consistently effective.

Competitive modulation of Kv1.2 gating by LMAN2 and Slc7a5

This study identifies Slc7a5 and LMAN2 as regulators of Kv1.2 channel gating, showing they compete for interaction with the voltage sensor, leading to complex voltage-dependent behavior.

Regulation of Kv1.2 redox-sensitive gating by the transmembrane lectin LMAN2

This study identifies LMAN2 as a regulatory protein that modulates redox-sensitive gating of Kv1.2 channels by altering activation kinetics and redox sensitivity.

Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels

This study shows that Slc7a5 regulates Kv1.1 channels similarly to Kv1.2, with sensitivity controlled by voltage-sensing domain exchange.

ER stress-mediated BK dysfunction in the DRG underlies pain in a model of multiple sclerosis

This study shows that ER stress in DRG neurons contributes to pain in MS and that ER stress modulators can reduce pain hypersensitivity in an EAE model.