Muhammad Saad Yousuf

This study examines the anatomical changes in the human lumbar spinal dorsal horn in relation to chronic lower limb pain and finds no association with neuronal density or inhibitory neuron loss.

This study shows that eIF3d modulates pain hypersensitivity under specific stress conditions but not in all pain models.

The paper investigates neurodegeneration in dorsal root ganglia across diabetes and diabetic painful neuropathy stages, identifying early molecular changes and highlighting the need for early intervention.

This paper characterizes the cyanobacterial metabolite Veraguamide E, showing it binds the sigma-2 receptor with high affinity, modulates calcium signaling in neurons, and lacks cytotoxicity.

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

The paper maps molecular features of human spinal cord dorsal and ventral horns, identifying neuronal types and sex-specific glial differences using single-nucleus sequencing and spatial transcriptomics.

This paper introduces a method to preserve human dorsal root ganglion neurons using Hibernate media, enabling easier access and transport for research.

This paper uses spatial transcriptomics to analyze human sympathetic chain ganglia in diabetes, identifying neuronal and non-neuronal changes linked to autonomic dysfunction.

The paper shows OSM-OSMR signaling via MAPKs drives transcriptomic changes in human DRG linked to neuropathic pain.

This paper shows that diroximel fumarate (DRF) reduces MGO-induced pain hypersensitivity in mice by activating Nrf2 and decreasing ISR activation in DRG neurons.

This study shows ephrin-B2 promotes nociceptive plasticity and hyperalgesic priming in mice and humans through MNK-eIF4E signaling in DRG neurons.

This paper identifies FEM-1689 as a σ2R/TMEM97 ligand that alleviates neuropathic pain by inhibiting the integrated stress response in mice and human sensory neurons.

This study shows that ER stress in DRG neurons contributes to pain in MS and that ER stress modulators can reduce pain hypersensitivity in an EAE model.