Engineered flavonoid disrupts mitochondrial AIF/CHCHD4 complex for targeted cancer therapy
Hong-Toan Lai, Daniela Dias‐Pedroso, Maria Eugénia Marques Da Costa, Romain Fernandes, Tran Ngoc Anh Nguyen, Olivia Bawa, Pierre Khneisser, João Gabriel Silva, Yassine Khalij, Michelangelo Campanella, John Griffith Jones, Svetlana Dokudovskaya, Guido Kroemer, Antonin Marchais, Nathalie Gaspar, , Catherine Brenner
This paper identifies M30-E05, an engineered flavonoid that disrupts the AIF/CHCHD4 mitochondrial complex, reducing cancer cell viability and tumor growth in xenograft models.
Acta Pharmaceutica Sinica B · Jun 15, 2026Peer-reviewedPharmacology & Toxicology