Nathalie Gaspar

Engineered flavonoid disrupts mitochondrial AIF/CHCHD4 complex for targeted cancer therapy

This paper identifies M30-E05, an engineered flavonoid that disrupts the AIF/CHCHD4 mitochondrial complex, reducing cancer cell viability and tumor growth in xenograft models.

Combined inhibition of AIF/CHCHD4 interaction and GLS1 to exploit metabolic vulnerabilities in pediatric osteosarcoma

This study identifies a metabolic vulnerability in osteosarcoma by combining AIF/CHCHD4 inhibition and GLS1 suppression, showing synergy between mitoxantrone and telaglenastat in vitro and in vivo.

CellsFromSpace: A fast, accurate and reference-free tool to deconvolve and annotate spatially distributed Omics data

CellsFromSpace is a reference-free tool for deconvolving and annotating spatial transcriptomic data, outperforming existing methods in accuracy and speed across multiple technologies.