Maria Eugénia Marques Da Costa

This paper identifies M30-E05, an engineered flavonoid that disrupts the AIF/CHCHD4 mitochondrial complex, reducing cancer cell viability and tumor growth in xenograft models.

This study identifies a metabolic vulnerability in osteosarcoma by combining AIF/CHCHD4 inhibition and GLS1 suppression, showing synergy between mitoxantrone and telaglenastat in vitro and in vivo.

The paper introduces a PDX platform for pediatric cancers, providing in vivo drug testing models and molecular data to aid in therapy development.

CellsFromSpace is a reference-free tool for deconvolving and annotating spatial transcriptomic data, outperforming existing methods in accuracy and speed across multiple technologies.