Guido Kroemer

Glycometabolic, inflammatory and exocrine plasma proteins predict cancer in individuals with cardiovascular disease

The paper identifies a plasma protein signature that predicts cancer in patients with cardiovascular disease, using data from two cohorts.

Engineered flavonoid disrupts mitochondrial AIF/CHCHD4 complex for targeted cancer therapy

This paper identifies M30-E05, an engineered flavonoid that disrupts the AIF/CHCHD4 mitochondrial complex, reducing cancer cell viability and tumor growth in xenograft models.

Combined inhibition of AIF/CHCHD4 interaction and GLS1 to exploit metabolic vulnerabilities in pediatric osteosarcoma

This study identifies a metabolic vulnerability in osteosarcoma by combining AIF/CHCHD4 inhibition and GLS1 suppression, showing synergy between mitoxantrone and telaglenastat in vitro and in vivo.

Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury

The paper shows that Treg cells use IFNγ and IL-10 to promote intestinal stem cell growth and repair after injury.

Lysosomal membrane permeabilization enhances the anticancer effects of RNA Polymerase I transcription inhibitors

This study shows that lysosomal membrane permeabilization enhances the effectiveness of RNA Polymerase I inhibitors against cancer cells.

Spermidine alleviates depression via control of the stress response

This study shows that spermidine supplementation improves depression symptoms by enhancing autophagy and correcting polyamine imbalances in both humans and mice.

UPMaBoSS: a novel framework for dynamic cell population modeling.

UPMaBoSS simulates cell population dynamics by extending MaBoSS to model interactions and death/division, revealing TNF-induced resistance mechanisms.