Author

O. Francis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Organism:plant (other)· 1 Assay:proteomics· 1

Frequent Co-Authors

L. Wooldridge· 2 shared M. Bailey· 2 shared R. Burt· 2 shared A. Davidson· 1 shared A. Finn· 1 shared A. Fuller· 1 shared A. Harrison· 1 shared A. J. Mulholland· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

L. Wooldridge

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Antibodies generated in vitro and in vivo elucidate design of a thermostable ADDomer COVID-19 nasal nanoparticle vaccine

D. Buzas, H. A. Bunzel, O. Staufer, E. Milodowski, G. Edmonds, J. Bufton, B. Vidana Matteo, S. Yadav, K. Gupta, C. Fletcher, M. Kavanagh Williamson, A. Harrison, U. Borucu, J. Capin, O. Francis, , I. Berger

This study develops a thermostable ADDomer-based nanoparticle vaccine that neutralizes SARS-CoV-2 and cross-reacts with VOCs, demonstrating its potential for nasal administration.

bioRxiv · Mar 17, 2023Biochemistry

Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in outbred and inbred Babraham pigs

M. Edmans, A. Mcnee, E. Porter, E. Vatzia, B. Paudyal, V. Martini, S. Gubbins, O. Francis, R. Harley, A. Thomas, R. Burt, S. Morgan, A. Fuller, A. Sewell, B. Charleston, , E. Tchilian

This study compares T cell and antibody responses to H1N1pdm09 infection in inbred and outbred pigs, showing similar immune responses despite differences in genetic background.

bioRxiv · Oct 28, 2020Immunology

CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor

M. Clement, L. Knezevic, T. Dockree, J. E. McLaren, K. Ladell, K. Miners, S. Llewellyn-Lacey, O. Francis, A. K. Sewell, J. S. Bridgeman, D. A. Price, H. A. van den Berg, L. Wooldridge

The paper shows that CD8 coreceptor interactions can alter the agonist hierarchy of peptide ligands recognized by TCRs, affecting antigen sensitivity without changing TCR structure.

bioRxiv · Sep 23, 2020Immunology