Author

H. A. Rothan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 6

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

H. Pathak· 3 shared J. P. Natekar· 3 shared K. Arora· 3 shared M. Kumar· 3 shared P. Kumari· 3 shared S. Stone· 3 shared S. Sharma· 2 shared A. Gribenko· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

H. Pathak

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Differential pathogenesis of SARS-CoV-2 variants of concern in human ACE2-expressing mice

J. P. Natekar, H. Pathak, S. Stone, P. Kumari, S. Sharma, K. Arora, H. A. Rothan, M. Kumar

This study compares the pathogenesis of SARS-CoV-2 variants in human ACE2-expressing mice, finding that some variants are more lethal and replicate more in the lungs and brain.

bioRxiv · Apr 4, 2022Microbiology

Nirmatrelvir, an orally active Mpro inhibitor, is a potent inhibitor of SARS-CoV-2 Variants of Concern

D. K. Rai, I. Yurgelonis, P. McMonagle, H. A. Rothan, L. Hao, A. Gribenko, E. Titova, B. Kreiswirth, K. M. White, Y. Zhu, A. S. Anderson, R. D. Cardin

This paper evaluates the antiviral activity of Nirmatrelvir against multiple SARS-CoV-2 variants using qRT-PCR in VeroE6 cells, showing potent inhibition across all tested variants.

bioRxiv · Jan 17, 2022Microbiology

SARS-CoV-2 variants of concern infect the respiratory tract and induce inflammatory response in wild-type laboratory mice

S. Stone, H. A. Rothan, J. P. Natekar, P. Kumari, S. Sharma, H. Pathak, K. Arora, T. T. Aurani, M. Kumar

This study infects wild-type mice with SARS-CoV-2 variants to show B.1.1.7 and B.1.351 replicate more efficiently and induce stronger inflammatory responses than the original B.1 virus.

bioRxiv · Sep 29, 2021Microbiology

Neuroinvasion and encephalitis following intranasal inoculation of SARS-CoV-2 in K18-hACE2 mice

P. Kumari, H. A. Rothan, J. P. Natekar, S. Stone, H. Pathak, P. G. Strate, K. Arora, M. A. Brinton, M. Kumar

This study shows that SARS-CoV-2 causes neuroinvasion and encephalitis in K18-hACE2 mice, leading to 100% mortality by day 6 post-infection.

bioRxiv · Dec 14, 2020Microbiology

Antiviral and Virucidal activities of sulphated polysaccharides against Japanese Encephalitis Virus.

H. A. Rothan

This study evaluates the antiviral activity of Carrageenan against Japanese Encephalitis Virus in vitro, finding it inhibits viral attachment and entry with EC50 of 15 µg/mL and CC50 over 200 µg/mL.

bioRxiv · Feb 11, 2020 · PreprintMicrobiology

Novel Quinazoline derivatives inhibited HCV Serine protease and viral replication in Huh-7 cells.

H. A. Rothan, R. Yusof, F. L. Faraj, T. C. Teoh

This study identifies quinazoline derivatives that inhibit HCV NS3-4A protease and viral replication in Huh-7 cells, with compound 4 showing the strongest activity.

bioRxiv · Jun 14, 2019 · PreprintMicrobiology