Selenocysteine metabolism is a targetable vulnerability in MYCN-amplified cancers
H. Alborzy, Z. Chen, U. Yildiz, F. Porto- Freitas, F. C. E. Vogel, J. Varga, J. Batani, C. Bartenhagen, W. Schmitz, G. Buechel, B. Michalke, J. Zheng, S. Meierjohann, E. Girardi, E. Espinet, , J. P. Friedmann Angeli
This study identifies LRP8 as a targetable vulnerability in MYCN-amplified neuroblastoma by showing its role in selenocysteine import and resistance to ferroptosis.
bioRxiv · May 17, 2022 · PreprintCancer Biology