E. Girardi

DEAD box RNA helicase 5 is a new pro-viral host factor for Sindbis virus infection

This study identifies DDX5 as a pro-viral host factor for Sindbis virus infection, showing its interaction with viral RNA and capsid protein, and demonstrating that its depletion reduces viral replication.

Selenocysteine metabolism is a targetable vulnerability in MYCN-amplified cancers

This study identifies LRP8 as a targetable vulnerability in MYCN-amplified neuroblastoma by showing its role in selenocysteine import and resistance to ferroptosis.

Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions

This study uses gain-of-function genetic screens in human cells to identify SLC transporters that overcome nutrient limitations by enhancing uptake of essential amino acids.

Human DICER helicase domain recruits PKR and modulates its antiviral activity

The paper shows that DICER's helicase domain recruits PKR and modulates its antiviral activity during alphavirus infection.

Proteomics-based determination of double stranded RNA interactome reveals known and new factors involved in Sindbis virus infection

This study identifies SFPQ as a new proviral factor involved in Sindbis virus infection by characterizing the dsRNA interactome using anti-dsRNA immunoprecipitation and mass spectrometry.

A systematic genetic interaction map of human solute carriers assigns a role to SLC25A51/MCART1 in mitochondrial NAD uptake

The paper systematically maps genetic interactions among human solute carriers, identifying SLC25A51/MCART1 as a mitochondrial NAD(H) transporter.

Genome-wide CRISPR-Cas9 screen reveals the importance of the heparan sulfate pathway and the conserved oligomeric golgi complex for synthetic dsRNA uptake and Sindbis virus infection

This study identifies the heparan sulfate pathway and COG4 in the Conserved Oligomeric Golgi complex as critical for dsRNA uptake and Sindbis virus infection in human cells.

Why most transporter mutations that cause antibiotic resistance are to efflux pumps rather than to import transporters

The paper shows that mutations increasing efflux pump activity are more effective than inhibiting uptake transporters in reducing antibiotic internal concentrations, suggesting efflux inhibition as a better strategy for combating resistance.

A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs

This study identifies SLC transporters critical for drug resistance using CRISPR screens in human cells, revealing widespread roles of SLCs in drug uptake and activity.

The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection

This study identifies SLC35A1 and SLC30A1 as host factors influencing cell survival during VSV infection through genetic screens and apoptosis analysis.

In silico prioritization of transporter-drug relationships from drug sensitivity screens

The paper uses pharmacogenomics data and regression models to identify drug-transporter relationships, uncovering both known and novel associations.

Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking

The paper uses genetic screens to identify SLC39A7 as a modulator of necroptosis by affecting TNF receptor trafficking and ER homeostasis.