S. van Dijk

A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth

This study identifies a nonenzymatic role of IRE1 in cancer cell cycle progression and tumor growth, independent of its kinase-RNase activity.

The ATP-exporting channel Pannexin-1 promotes CD8+ T cell effector and memory responses

This study shows that Pannexin-1 promotes CD8+ T cell effector and memory responses through distinct mechanisms involving eATP export and purinergic receptor activation.

Sublethal heat reduces overall reproductive investment and male allocation in a simultaneously hermaphroditic snail species

This study shows that sublethal heat reduces reproductive investment and male allocation in Lymnaea stagnalis snails, without affecting male mating motivation.

T cell-specific P2RX7 favors lung parenchymal CD4+ T cell accumulation in response to severe lung infections

This study shows that T cell-specific P2RX7 promotes lung CD4+ T cell accumulation and pathology during severe lung infections like TB and influenza.

The extracellular ATP receptor P2RX7 imprints a pro-memory transcriptional signature in effector CD8+ T cells

This study shows that P2RX7 expression in effector CD8+ T cells influences their differentiation into central and resident memory cells through transcriptional changes.

Bimodal Endocytic Probe for Three-Dimensional Correlative Light and Electron Microscopy

This paper introduces fBSA-Au, a bimodal endocytic tracer for 2D and 3D CLEM, enabling accurate registration of fluorescence to EM data with sub-200 nm precision.