Author

H. C. Clevers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:organoid / primary culture· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

B. M. Burgering· 1 shared E. C. A. Stigter· 1 shared G. Darmasaputra· 1 shared J. Drost· 1 shared M. C. Gulersonmez· 1 shared M. C. Ludikhuize· 1 shared M. Galli· 1 shared M. J. RodrIguez-Colman· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

B. M. Burgering

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Binucleated human hepatocytes arise through loss of membrane anchorage to the midbody during endomitosis

G. Darmasaputra, S. M. Chuva de Sousa Lopes, H. C. Clevers, M. Galli

This study identifies how human hepatocytes undergo endomitosis by losing membrane anchorage to the midbody, leading to binucleation, and shows the role of WNT signaling and E2F proteins in this process.

bioRxiv · Apr 13, 2023 · PreprintCell Biology

Rewiring glucose metabolism improves 5-FU efficacy in glycolytic p53-deficient colorectal tumors

M. C. Ludikhuize, S. Gevers, N. T. B. Nguyen, M. Meerlo, S. K. Shafiei Roudbari, M. C. Gulersonmez, E. C. A. Stigter, J. Drost, H. C. Clevers, B. M. Burgering, M. J. RodrIguez-Colman

This study shows that rewiring glucose metabolism enhances 5-FU efficacy in p53-deficient colorectal tumors by altering nucleotide pools without increasing toxicity in healthy cells.

bioRxiv · Nov 11, 2021Cancer Biology