Author

H. Carion

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:bacteria (other)· 5 Research Focus:host-pathogen & immune response· 5 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metagenomics· 1 Research Focus:protein folding & dynamics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. M. Deutschbauer· 3 shared A. P. Arkin· 3 shared J. Bondy-Denomy· 3 shared S. Silas· 3 shared B. A. Adler· 2 shared V. K. Mutalik· 2 shared A. E. Kazakov· 1 shared A. Fossati· 1 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersMicrobiology

A. M. Deutschbauer

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6 papers

Recent·Most cited

Activation of programmed cell death and counter-defense functions of phage accessory genes

S. Silas, H. Carion, K. S. Makarova, E. Laderman, D. S. Godinez, M. Johnson, A. Fossati, D. Swaney, M. Bocek, E. V. Koonin, J. Bondy-Denomy

The paper identifies and characterizes phage accessory genes (AGs) that activate host antiviral immunity, including programmed cell death, and explores their evolutionary implications.

bioRxiv · Apr 6, 2023 · PreprintMicrobiology

Translation-dependent downregulation of Cas12a mRNA by an anti-CRISPR protein

N. D. Marino, A. Talaie, H. Carion, M. C. Johnson, Y. Zhang, S. Silas, Y. Li, J. Bondy-Denomy

This study shows that AcrVA2 inhibits Cas12a mRNA translation, reducing its anti-phage activity and enabling specific inhibition of Cas12a orthologs.

bioRxiv · Nov 29, 2022 · PreprintMicrobiology

Barcoded overexpression screens in gut Bacteroidales identify genes with new roles in carbon utilization and stress resistance

Y. Y. Huang, M. N. Price, A. Hung, O. Gal-Oz, D. Ho, H. Carion, A. M. Deutschbauer, A. P. Arkin

The paper identifies new gene functions in gut Bacteroidales using a barcoded overexpression screen, revealing roles in carbon utilization and stress resistance.

bioRxiv · Oct 10, 2022 · PreprintMicrobiology

Bacteriophages antagonize cGAS-like immunity in bacteria

E. Huiting, J. Athukoralage, J. Guan, S. Silas, H. Carion, J. Bondy-Denomy

The paper identifies a phage-encoded antagonist of the bacterial CBASS immunity system, showing it is necessary for phage replication and demonstrating CBASS functions as a natural anti-phage immune system.

bioRxiv · Mar 30, 2022 · PreprintMicrobiology

Parallel multicopy-suppressor screens reveal convergent evolution of phage-encoded single gene lysis proteins

B. A. Adler, K. Chamakura, H. Carion, J. Krog, A. M. Deutschbauer, R. F. Young, V. K. Mutalik, A. P. Arkin

The paper identifies host suppressors of phage-encoded single gene lysis proteins, revealing convergent evolution and common mechanisms across diverse phages.

bioRxiv · Jan 20, 2022 · PreprintMicrobiology

The Genetic Basis of phage susceptibility, cross-resistance and host-range in Salmonella

B. A. Adler, A. E. Kazakov, C. Zhong, H. Liu, E. Kutter, L. M. Lui, T. N. Nielsen, H. Carion, A. M. Deutschbauer, V. K. Mutalik, A. P. Arkin

This study identifies 301 host factors in Salmonella involved in phage resistance, reveals cross-resistance mechanisms between RpoS and RpoN, and shows additional constraints define phage host range.

Microbiology · Dec 1, 2021Peer-reviewedMicrobiology