Author

H. De Koning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:Arabidopsis· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

L. J. Morrison· 2 shared M. P. Barrett· 2 shared S. Jayaraman· 2 shared A. Schnaufer· 1 shared A.-M. Donachie· 1 shared B. Wickstead· 1 shared C. Gadelha· 1 shared D. Horn· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

L. J. Morrison

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential drug sensitivity

P. C. Steketee, E. A. Dickie, J. Iremonger, K. Crouch, E. Paxton, S. Jayaraman, O. A. Alfituri, G. Awuah-Mensah, R. Ritchie, A. Schnaufer, H. De Koning, C. Gadelha, B. Wickstead, M. P. Barrett, L. J. Morrison

This study compares metabolism between Trypanosoma congolense and T. brucei, finding differences in glucose uptake, glycolytic endpoints, and drug sensitivity.

bioRxiv · Jan 5, 2021Microbiology

Diminazene resistance in Trypanosoma congolense is linked to reduced mitochondrial membrane potential and not to reduced transport capacity

H. De Koning, L. V. Carruthers, J. C. Munday, G. U. Ebiloma, P. Steketee, S. Jayaraman, G. D. Campagnaro, M. A. Ungogo, A.-M. Donachie, T. G. Rowan, R. Peter, L. J. Morrison, M. P. Barrett

This study investigates diminazene resistance in Trypanosoma congolense and finds that resistance is due to reduced mitochondrial membrane potential rather than reduced drug transport capacity.

bioRxiv · Jul 28, 2020Microbiology

Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei

J. F. Quintana Alcala, J. A. Bueren-Calabuig, F. Zuccotto, H. de Koning, D. Horn, M. C. Field

The paper shows that instability of TbAQP2 contributes to drug resistance in Trypanosoma brucei by affecting its folding, oligomerization, and localization.

bioRxiv · Feb 22, 2020Microbiology