Loss of Hem1 disrupts macrophage function and impacts on migration, phagocytosis and integrin-mediated adhesion
S. Stahnke, H. Döring, C. Kusch, D. J. J. de Gorter, S. Dütting, A. Guledani, I. Pleines, M. Schnoor, M. Sixt, R. Geffers, M. Rohde, M. Müsken, F. Kage, A. Steffen, J. Faix, , T. E. B. Stradal
This study shows that Hem1 deficiency impairs macrophage migration, phagocytosis, and integrin-mediated adhesion by disrupting WRC function and paxillin phosphorylation.
Current Biology · May 1, 2021Peer-reviewedCell Biology