F. Kage

Long-chain fatty acyl-coenzyme A activates the mitochondrial fission factors MiD49 and MiD51 by inducing their oligomerization

This study shows that long-chain fatty acyl-CoA activates mitochondrial fission proteins MiD49 and MiD51 by inducing their oligomerization, which enhances DRP1 GTPase activity and promotes mitochondrial fission.

Lamellipodia-like actin networks in cells lacking WAVE Regulatory Complex

The paper shows that lamellipodia-like structures can form without the WAVE Regulatory Complex by using Rac and Cdc42, but not Ena/VASP family proteins.

Loss of Hem1 disrupts macrophage function and impacts on migration, phagocytosis and integrin-mediated adhesion

This study shows that Hem1 deficiency impairs macrophage migration, phagocytosis, and integrin-mediated adhesion by disrupting WRC function and paxillin phosphorylation.

Induced Arp2/3 complex depletion increases FMNL2/3 formin expression and filopodia formation

This study shows that acute Arp2/3 complex depletion increases FMNL2/3 formin expression and filopodia formation in fibroblasts, despite reduced actin turnover and impaired lamellipodia formation.

RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE Regulatory Complex-binding

This study shows RhoG and Cdc42 can drive lamellipodia formation independently of Rac by directly interacting with the WAVE Regulatory Complex.