Author

K. Rajalingam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

A. Ernst· 1 shared A. Mariappan· 1 shared A. Papantonis· 1 shared B. Dynlacht· 1 shared B. M. Grebbin· 1 shared B. Thiede· 1 shared F. Sicheri· 1 shared G. C. Callaini· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. Ernst

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Author profile →

3 papers

Recent·Most cited

ERK3/MAPK6 dictates Cdc42/Rac1 activity and ARP2/3-dependent actin polymerization

K. Bogucka-Janczi, G. Harms, M. May-Coissieux, M. Bentires-Alj, B. Thiede, K. Rajalingam

This study identifies ERK3 as a regulator of Cdc42/Rac1 activity and ARP2/3-dependent actin polymerization, showing its role in filopodia formation and cell migration.

bioRxiv · Oct 12, 2022Cell Biology

Cilium induction triggers differentiation of glioma stem cells

G. Goranci-Buzhala, A. Mariappan, L. Ricci-Vitiani, N. Josipovic, S. Pacion, M. Gottardo, J. Ptok, G. C. Callaini, K. Rajalingam, B. Dynlacht, K. Hadian, A. Papantonis, R. Pallini, J. Gopalakrishnan

This study shows that inducing ciliogenesis in glioma stem cells (GSCs) promotes their differentiation and prevents brain infiltration, suggesting cilium induction as a therapeutic strategy for glioblastoma.

bioRxiv · Dec 23, 2020Cell Biology

Novel Conformation Specific Inhibitors of Activated GTPases reveal Ras-dependency of Patient-Derived Cancer Organoids

S. Wiechmann, P. Maisonneuve, B. M. Grebbin, M. Hoffmeister, M. Kaulich, H. Clevers, K. Rajalingam, I. Kurinov, H. F. Farin, F. Sicheri, A. Ernst

The paper develops RBD variants that inhibit Ras effector binding, inducing senescence in non-tumorigenic cells and revealing Ras dependency in cancer organoids.

bioRxiv · Aug 28, 2019Cancer Biology