Author

I. Kurinov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:organoid / primary culture· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

A. A. Z. Khalifa· 1 shared A. Ernst· 1 shared B. M. Grebbin· 1 shared C. Black· 1 shared D. Pelletier· 1 shared F. Sicheri· 1 shared G. Brouhard· 1 shared H. Clevers· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

A. A. Z. Khalifa

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2 papers

Recent·Most cited

Crystal structure of human PACRG in complex with MEIG1

N. Khan, D. Pelletier, S. Veyron, N. Croteau, M. Ichikawa, C. Black, A. A. Z. Khalifa, S. Chaaban, I. Kurinov, G. Brouhard, K. H. Bui, J.-F. Trempe

The paper reports the crystal structure of human PACRG with MEIG1 and models its role in microtubule junctions, revealing interactions with tubulin and evolutionary insights.

bioRxiv · Sep 27, 2019Cell Biology

Novel Conformation Specific Inhibitors of Activated GTPases reveal Ras-dependency of Patient-Derived Cancer Organoids

S. Wiechmann, P. Maisonneuve, B. M. Grebbin, M. Hoffmeister, M. Kaulich, H. Clevers, K. Rajalingam, I. Kurinov, H. F. Farin, F. Sicheri, A. Ernst

The paper develops RBD variants that inhibit Ras effector binding, inducing senescence in non-tumorigenic cells and revealing Ras dependency in cancer organoids.

bioRxiv · Aug 28, 2019Cancer Biology