Lung-selective Cas13d-based nanotherapy inhibits lethal SARS-CoV-2 infection by targeting host protease Ctsl
Z. Cui, C. Zeng, F. Huang, F. Yuan, J. Yan, Y. Zhao, J. Huang, H. F. Staats, J. I. Everitt, G. D. Sempowski, H. Wang, Y. Dong, S.-L. Liu, Q. Wang
This paper develops a lung-selective Cas13d-based nanotherapy targeting Ctsl to inhibit SARS-CoV-2 infection, showing improved survival and reduced viral burden in mice.
bioRxiv · Oct 3, 2021 · PreprintMicrobiology