Author

G. D. Sempowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 6 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Organism:non-human primate· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2

Frequent Co-Authors

B. F. Haynes· 6 shared K. Mansouri· 6 shared R. J. Edwards· 6 shared R. Parks· 6 shared D. Li· 5 shared K. O. Saunders· 5 shared M. Barr· 5 shared D. C. Montefiori· 4 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

6 shared papersImmunology

B. F. Haynes

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

R. D. Malewana, V. Stalls, A. May, X. Lu, D. R. Martinez, A. Schafer, D. Li, M. Barr, L. L. Sutherland, E. Lee, R. Parks, W. E. Beck, A. Newman, K. W. Bock, M. Minai, , K. O. Saunders

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

bioRxiv · Dec 18, 2023 · PreprintImmunology

A class of antibodies that overcome a steric barrier to cross-group neutralization of influenza viruses

H. C. Simmons, A. Watanabe, T. H. Oguin, G. D. Sempowski, M. Kuraoka, G. H. Kelsoe, K. R. McCarthy

This paper identifies a class of antibodies that neutralize both H1 and H3 influenza viruses by overcoming a steric barrier at the HA RBS.

bioRxiv · Apr 1, 2023 · PreprintMicrobiology

Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

S. Luo, J. Zhang, A. J. B. Kreutzberger, A. Eaton, R. J. Edwards, C. Jing, H.-Q. Dai, G. D. Sempowski, K. Cronin, R. Parks, A. Y. Ye, K. Mansouri, M. Barr, N. Pishesha, A. C. Williams, , F. W. Alt

The paper describes a humanized antibody, SP1-77, that neutralizes all SARS-CoV-2 variants by blocking membrane fusion instead of ACE2 receptor binding.

bioRxiv · Jun 26, 2022 · PreprintImmunology

Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

D. Li, D. R. Martinez, A. Schäfer, H. Chen, M. Barr, L. L. Sutherland, E. Lee, R. Parks, D. Mielke, W. Edwards, A. Newman, K. W. Bock, M. Minai, B. M. Nagata, M. Gagne, , B. F. Haynes

This study shows a nanoparticle vaccine induces broad neutralizing antibodies against multiple SARS-CoV-2 variants and protects non-human primates and mice from viral challenges.

bioRxiv · Jan 26, 2022Immunology

Structural diversity of the SARS-CoV-2 Omicron spike

S. Gobeil, R. Henderson, V. Stalls, K. Janowska, X. Huang, A. May, M. Speakman, E. Beaudoin, K. Manne, D. Li, R. Parks, M. Barr, M. Deyton, M. Martin, K. Mansouri, , P. Acharya

The paper compares cryo-EM structures of SARS-CoV-2 Omicron and Delta spikes to analyze conformational changes affecting immune evasion and transmissibility.

bioRxiv · Jan 25, 2022Biochemistry

Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging

S. A. Sonar, J. L. Uhrlaub, C. P. Coplen, G. D. Sempowski, J. A. Dudakov, M. R. M. van den Brink, B. J. LaFleur, M. Jergovic, J. Nikolich-Zugich

This study shows that skin-draining lymph nodes atrophy early in mice, leading to impaired immune function and reduced effector cell production in older age.

bioRxiv · Nov 22, 2021Immunology

Lung-selective Cas13d-based nanotherapy inhibits lethal SARS-CoV-2 infection by targeting host protease Ctsl

Z. Cui, C. Zeng, F. Huang, F. Yuan, J. Yan, Y. Zhao, J. Huang, H. F. Staats, J. I. Everitt, G. D. Sempowski, H. Wang, Y. Dong, S.-L. Liu, Q. Wang

This paper develops a lung-selective Cas13d-based nanotherapy targeting Ctsl to inhibit SARS-CoV-2 infection, showing improved survival and reduced viral burden in mice.

bioRxiv · Oct 3, 2021 · PreprintMicrobiology

Influenza viral particles harboring the SARS-CoV-2 spike RBD as a combination respiratory disease vaccine

R. R. Chaparian, A. T. Harding, K. Riebe, A. Karlsson, G. D. Sempowski, N. S. Heaton, B. E. Heaton

This paper develops a combination vaccine using recombinant influenza A virus to deliver SARS-CoV-2 spike RBD, showing protection against both pathogens.

bioRxiv · Apr 30, 2021 · PreprintMicrobiology

SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys

K. O. Saunders, E. Lee, R. Parks, D. R. Martinez, D. Li, H. Chen, R. J. Edwards, S. M. C. Gobeil, M. Barr, K. Mansouri, S. M. Alam, L. L. Sutherland, F. Cai, A. Sanzone, M. Berry, , B. F. Haynes

This study shows that SARS-CoV-2 vaccines induce neutralizing antibodies against SARS-CoV-1, SARS-CoV-2, and batCoVs in monkeys.

bioRxiv · Feb 17, 2021 · PreprintImmunology

Cold sensitivity of the SARS-CoV-2 spike ectodomain

R. J. Edwards, K. Mansouri, V. Stalls, K. Manne, B. Watts, R. Parks, K. Janowska, S. M. C. Gobeil, M. Kopp, D. Li, X. Lu, Z. Mu, M. Deyton, T. Oguin, J. Sprenz, , P. Acharya

The paper shows that the SARS-CoV-2 spike ectodomain construct 2P is cold-sensitive, and this sensitivity is resolved in a down-state stabilized spike.

bioRxiv · Jul 12, 2020Biochemistry