Author

H. Gandhi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Assay:imaging· 4 Approach:microscopy & imaging analysis· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

S. Arumugam· 4 shared A. Patil· 3 shared K. Gaus· 3 shared U. K. Moorthi· 3 shared H. M. York· 2 shared A. A. Abdeen· 1 shared A. Bhowmik· 1 shared A. Fulcher· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersBiophysics

S. Arumugam

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Author profile →

7 papers

Recent·Most cited

DeepVariant calling provides insights into race diversity and its implication for sorghum breeding

P. Ruperao, P. Gandham, D. A. Odeny, S. Selvanayagam, N. Thirunavukkarasu, R. R. Das, M. Srikanda, H. Gandhi, E. Habyarimana, E. Manyasa, B. Nebie, S. P. Deshpande, A. Rathore

The paper uses deep learning to analyze sorghum genetic diversity, identifying 1.7 million SNPs and 2,370 genes under selection linked to domestication traits.

bioRxiv · Sep 6, 2022 · PreprintPlant Biology

Deterministic Early Endosomal Maturations Emerge From a Stochastic Trigger-and-Convert Mechanism

H. M. York, K. Joshi, C. S. Wright, L. Z. Kreplin, S. Rodgers, U. K. Moorthi, H. Gandhi, A. Patil, C. Mitchell, S. Iyer-Biswas, S. Arumugam

The paper tracks endosomal maturation events using advanced imaging and simulations, revealing that maturation is driven by heterotypic EEA1-mediated interactions rather than autonomous stochastic processes.

bioRxiv · Apr 15, 2022Biophysics

MOV10 facilitates messenger RNA decay in an N6-methyladenosine (m6A) dependent manner to maintain the mouse embryonic stem cells state

M. Mehravar, Y. Kumar, M. Olshansky, P. Dakle, M. J. Bullen, V. K. Pandey, D. Bansal, C. Dent, D. Hathiwala, Z. Zhang, H. Gandhi, A. Fulcher, C. Huang, J. Price, S. Arumugam, , P. P. Das

The paper identifies MOV10 as a new m6A-reader that facilitates mRNA decay via m6A to regulate the WNT/β-CATENIN pathway and maintain mouse embryonic stem cell state.

bioRxiv · Aug 11, 2021 · PreprintBiochemistry

Rapid Whole Cell Imaging Reveals A Calcium-APPL1-Dynein Nexus That Regulates Cohort Trafficking of Stimulated EGF Receptor

H. York, A. Patil, U. K. Moorthi, A. Kaur, A. Bhowmik, G. J. Hyde, H. Gandhi, K. Gaus, S. Arumugam

The paper uses whole-cell imaging to reveal a calcium-APPL1-dynein mechanism that directs EGFR trafficking to the peri-nuclear region.

Communications Biology · Feb 17, 2021Peer-reviewedCell Biology

Combination of photoactivation with lattice light-sheet imaging reveals untemplated, lamellar ruffle generation by PA-Rac1

F. Leyden, S. Uthishtran, U. K. Moorthi, H. M. York, A. Patil, H. Gandhi, E. P. Petrov, S. Arumugam

The paper uses optogenetic PA-Rac1 and lattice light-sheet imaging to show Rac1 drives untemplated lamellar ruffle formation without a template.

bioRxiv · Sep 1, 2020 · PreprintBiophysics

Geometric regulation of histone state directs melanoma reprogramming

J. Lee, T. G. Molley, C. H. Seward, A. A. Abdeen, H. Zhang, X. Wang, H. Gandhi, J.-L. Yang, K. Gaus, K. A. Kilian

This study identifies a link between geometric features of melanoma aggregates and reprogramming to stem cell-like initiating cells through histone modifications.

bioRxiv · Dec 11, 2019Cancer Biology

Single molecule localization microscopy with autonomous feedback loops for ultrahigh precision

S. Coelho, J. baek, M. S. Graus, J. M. Halstead, P. R. Nicovich, K. Feher, H. Gandhi, K. Gaus

This paper develops an actively stabilized microscope with feedback loops to improve SMLM precision, enabling nanometer-scale distance measurements in cells.

bioRxiv · Dec 5, 2018 · PreprintBiophysics