P. Mertins

Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface

The paper develops methods to collect intestinal interstitial fluid from different segments and shows segment-specific differences in microbiota-derived metabolites, cytokines, and proteins compared to plasma and serum.

Combining data independent acquisition with spike-in SILAC (DIA-SiS) improves proteome coverage and quantification

This paper introduces DIA-SiS, a method combining DIA with spike-in SILAC to improve proteome coverage and quantification, showing better performance than label-free approaches.

Comprehensive characterization of the viscoelastic properties of Bovine Submaxillary Mucin (BSM) hydrogels and the effect of additives

This study characterizes the viscoelastic properties of Bovine Submaxillary Mucin (BSM) hydrogels and examines the effects of additives on their rheological behavior.

Human ADA2 deficiency is characterized by the absence of an intracellular hypoglycosylated form of adenosine deaminase 2

The paper identifies an intracellular hypoglycosylated form of ADA2 absent in DADA2 patients, linking its absence to reduced deaminase activity and variant pathogenicity.

Identification of tumor-specific MHC ligands through improved biochemical isolation and incorporation of machine learning

This paper improves the isolation of tumor-specific MHC ligands through hydrophobicity and post-translational modification considerations and introduces a machine learning model for predicting MHC ligand presentation.

Mice with renal-specific alterations of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors

The paper generates kidney organoids and genetic mouse models with altered stem cell signaling, finding CKD symptoms but no tumors.

Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators

This study investigates monoallelic Prdm16 mutation in mice, revealing sex-specific cardiac metabolic dysregulation and identifying Pyroxd2 and Pbxip1 as novel metabolic regulators.

Amplicon structure creates collateral therapeutic vulnerability in cancer

The paper identifies DDX1 as a passenger gene co-amplified with MYCN in cancer, showing that its aberrant expression creates a therapeutic vulnerability through mTORC1 dependency.

Implementing solid-phase-enhanced sample preparation for Co-Immunoprecipitation with Mass Spectrometry for C. elegans

The paper optimizes CoIP-MS for C. elegans by integrating SP3 sample preparation, demonstrating high accuracy and robustness in detecting protein-protein interactions.

SUMOylation of the chromodomain factor MRG-1 in C. elegans affects chromatin-regulatory dynamics

This study shows that SUMOylation of MRG-1 in C. elegans alters its chromatin-binding profile, suggesting a role for SUMOylation in epigenetic regulation.

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

This study identifies an early interferon-stimulated gene (ISG) upregulation as a protective immune signature in non-pneumonic SARS-CoV-2 infection, preventing progression to pneumonia.

Exploiting a PAX3-FOXO1-induced synthetic lethal ATR dependency for rhabdomyosarcoma therapy

This study identifies ATR as a synthetic lethal target in PAX3-FOXO1-driven rhabdomyosarcoma, showing ATR inhibition enhances PARP inhibitor efficacy and is tolerated in patients.

YAP and β-catenin co-operate to drive oncogenesis in basal breast cancer

This study shows YAP and β-catenin cooperate in basal breast cancer to drive CSCs, with targeting this complex as a potential therapeutic strategy.

Mapping the unique and shared functions of oncogenic KRAS and RIT1 with proteome and transcriptome profiling

This study compares proteomic and transcriptomic profiles of KRAS and RIT1 mutant lung cells to identify shared and divergent functions in oncogenic signaling.

UbiFast, a rapid and deep-scale ubiquitylation profiling approach for biology and translational research

UbiFast enables rapid, high-throughput ubiquitylation profiling of up to 10,000 sites from small tissue samples, with applications in cancer research.

Spatial Organization of Rho GTPase signaling by RhoGEF/RhoGAP proteins

The paper characterizes RhoGEF/RhoGAP substrate specificities, localization, and interactomes to reveal their role in spatially organizing Rho signaling.