RepairSwitch: simultaneous functional assessment of homologous recombination and end joining DNA repair pathways in living cells
R. C. Steinberg, J. Liu, A. M. Vaghasia, H. Giovinazzo, M.-T. N. Pham, D. Tselenchuk, R. Chikarmane, M. C. Haffner, W. G. Nelson, S. Yegnasubramanian
The paper introduces RepairSwitch, a flow cytometry assay to simultaneously measure HR and NHEJ DNA repair rates in living cells, and demonstrates its utility in assessing drug and genetic perturbations.
bioRxiv · Jan 17, 2023 · PreprintCell Biology