Author

W. G. Nelson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

S. Yegnasubramanian· 4 shared A. M. De Marzo· 3 shared A. M. Vaghasia· 2 shared J. Hicks· 2 shared M. C. Haffner· 2 shared M.-T. N. Pham· 2 shared R. Chikarmane· 2 shared A. Archey· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCancer Biology

S. Yegnasubramanian

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4 papers

Recent·Most cited

Arrested Agonist Paradigm For Selective Radiosensitization of Prostate Cancer

J. B. Coulter, M. Haffner, Y. Zhang, H. Zhou, M.-T. N. Pham, J. Chen, R. Chikarmane, A. Mishra, M. S. Mehl, S. Kazibwe, K. Choi, A. Archey, S. Valluri, S. E. Lupold, D. Song, , S. Yegnasubramanian

This paper identifies hydroxyflutamide as an AR arrested agonist that induces DNA damage in prostate cancer cells, enabling selective radiosensitization without promoting growth.

bioRxiv · Oct 1, 2023 · PreprintCancer Biology

Progressive spreading of DNA methylation in the GSTP1 promoter CpG island across transitions from precursors to invasive prostate cancer

H. Gupta, H. Inoue, Y. Nakai, M. Nakayama, T. Jones, J. Hicks, B. Kumar, M. Gurel, W. G. Nelson, A. M. De Marzo, S. Yegnasubramanian

The paper examines DNA methylation patterns in the GSTP1 promoter across prostate cancer progression stages and finds increasing methylation from normal to cancerous lesions.

Cancer Prevention Research · Aug 1, 2023Peer-reviewedCancer Biology

RepairSwitch: simultaneous functional assessment of homologous recombination and end joining DNA repair pathways in living cells

R. C. Steinberg, J. Liu, A. M. Vaghasia, H. Giovinazzo, M.-T. N. Pham, D. Tselenchuk, R. Chikarmane, M. C. Haffner, W. G. Nelson, S. Yegnasubramanian

The paper introduces RepairSwitch, a flow cytometry assay to simultaneously measure HR and NHEJ DNA repair rates in living cells, and demonstrates its utility in assessing drug and genetic perturbations.

bioRxiv · Jan 17, 2023 · PreprintCell Biology

PHENOTYPIC CHARACTERIZATION OF TWO NOVEL CELL LINE MODELS OF CASTRATION RESISTANT PROSTATE CANCER.

M. C. Haffner, A. Bhamidipati, H. K. Tsai, D. M. Esopi, A. M. Vaghasia, J.-Y. Low, R. A. Patel, G. Guner, M.-T. Pham, N. Castagna, J. Hicks, N. Wyhs, R. Aebersold, A. M. De Marzo, W. G. Nelson, , S. Yegnasubramanian

This study develops two novel castration-resistant prostate cancer cell lines and characterizes their transcriptomic and proteomic profiles to understand resistance mechanisms.

bioRxiv · Jul 4, 2021 · PreprintCancer Biology