Author

H. Gula

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Pathology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Organism:mouse· 2 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

G. Randall· 4 shared V. Nicolaescu· 3 shared A. Mohamed· 2 shared A. Tomatsidou· 2 shared C. Dann· 2 shared D. Batlle· 2 shared D. Silva· 2 shared D. Yang· 2 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersPathology

G. Randall

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Superiority of intranasal over systemic administration of bioengineered soluble ACE2 for survival and brain protection against SARS-CoV-2 infection

L. Hassler, J. Wysocki, J. T. Ahrendsen, M. Ye, I. Gelarden, V. Nicolaescu, A. Tomatsidou, H. Gula, C. Cianfarini, N. Khurram, Y. Kanwar, B. D. Singer, G. Randall, D. M. Missiakas, J. Henkin, D. Batlle

This study compares intranasal and systemic administration of bioengineered soluble ACE2 in mice, finding intranasal delivery provides better survival and brain protection against SARS-CoV-2.

bioRxiv · Dec 5, 2022 · PreprintPathology

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells

L. C. Nguyen, D. M. Renner, D. Silva, D. Yang, N. Parenti, K. M. Medina, V. Nicolaescu, H. Gula, N. Drayman, A. Valdespino, A. Mohamed, C. Dann, K. Wannemo, L. Robinson-Mailman, A. Gonzalez, , S. R. Weiss

This study compares how SARS-CoV-2 and other betacoronaviruses activate the IRE1α/XBP1 ER stress pathway in human lung cells, finding that SARS-CoV-2 only partially activates it, potentially evading host immune detection.

bioRxiv · Dec 30, 2021 · PreprintMicrobiology

A novel soluble ACE2 protein totally protects from lethal disease caused by SARS-CoV-2 infection

L. Hassler, J. Wysocki, I. Gelarden, A. Tomatsidou, H. Gula, V. Nicoleascu, G. Randall, J. Henkin, A. Yeldandi, D. Batlle

This paper describes a soluble ACE2 protein that prevents lethal SARS-CoV-2 infection in mice by blocking viral entry and reducing viral titers.

bioRxiv · Mar 12, 2021 · PreprintPathology

Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response

L. C. Nguyen, D. Yang, V. Nicolaescu, T. Best, S. Chen, J. B. Friesen, N. Drayman, A. Mohamed, C. Dann, D. Silva, H. Gula, K. A. Jones, J. M. Millis, B. C. Dickinson, S. Tay, , M. R. Rosner

This study shows that cannabidiol inhibits SARS-CoV-2 replication and enhances the host innate immune response in lung cells and human patients.

bioRxiv · Mar 10, 2021 · PreprintMicrobiology