H. J. Risselada

Cofilin-Driven Nuclear Deformation Drives Dendritic Cell Migration through the Extracellular Matrix

This study shows that cofilin-1 phosphorylation drives nuclear deformation and enhances dendritic cell migration through extracellular matrix.

PMIpred: A physics-informed web server for quantitative Protein-Membrane Interaction prediction

PMIpred predicts membrane-binding free energy and classifies peptides as non-binding, curvature sensing, or membrane binding using a transformer model trained on molecular dynamics data.

Physics-based generative model of curvature sensing peptides; distinguishing sensors from binders

The paper uses Evo-MD and a physics-trained neural network to identify curvature sensing peptides and distinguish them from binders using thermodynamic analysis.

Lipid Oxidation Controls Peptide Self-Assembly near Membranes

This study investigates how lipid oxidation affects peptide self-assembly near membranes, showing differential effects on amyloid-beta and antimicrobial peptides.

Membrane interactions of mitochondrial lipid transfer proteins

This study investigates how Ups1 interacts with mitochondrial membranes, showing its preference for positively curved membranes and its role in phosphatidic acid transfer.

Efficient quantification of lipid packing defect sensing by amphipathic peptides; comparing Martini 2 & 3 with CHARMM36

The paper introduces an efficient method to quantify lipid packing defect sensing by amphipathic peptides, comparing Martini 2 and 3 with CHARMM36 force fields.

Physics-based inverse design of cholesterolattracting transmembrane helices reveals aparadoxical role of hydrophobic length

This paper uses evolutionary algorithms and molecular dynamics to identify optimal cholesterol-attracting transmembrane helices, revealing a paradoxical role of hydrophobic length.

Size Matters: A Mechanistic Model of Nanoparticle Curvature Effects on Amyloid Fibril Formation

This study investigates how nanoparticle curvature affects amyloid fibril formation of different peptides, finding that smaller nanoparticles inhibit while larger ones accelerate aggregation.

TatA and TatB generate a hydrophobic mismatch that is important for function and assembly of the Tat translocon in Escherichia coli

The paper investigates how the hydrophobic mismatch between TatA and TatB TMHs affects Tat translocon function and assembly in E. coli.