J. Adler

Plasma membrane and cytoplasmic compartmentalization: a dynamic structural framework required for pollen tube tip growth

The paper maps plasma membrane and cytoplasmic domains in tobacco pollen tubes to understand tip growth mechanisms.

The TMPRSS2 non-protease domains regulating SARS-CoV-2 Spike in mediated virus entry

This study identifies phosphorylation sites in TMPRSS2's cytosolic tail and a binding region with Spike, showing they regulate SARS-CoV-2 entry pathways.

Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells

This study identifies recurring EPHB1 mutations in cancers, showing some impair cell compartmentalisation while others enhance it, with functional consequences on signalling pathways.

Tertiary Lymphoid Structures Sustain Cutaneous B cell Activity in Hidradenitis Suppurativa

The paper identifies tertiary lymphoid structures in HS lesions and shows B cell maturation and interactions with T cells and stroma.

A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients by phage display is binding to the ACE2-RBD interface and is tolerant to most known recently emerging RBD mutations

The paper describes the selection of a SARS-CoV-2 neutralizing antibody from COVID-19 patients using phage display, showing it binds the ACE2-RBD interface and remains effective against emerging RBD mutations.

Size Matters: A Mechanistic Model of Nanoparticle Curvature Effects on Amyloid Fibril Formation

This study investigates how nanoparticle curvature affects amyloid fibril formation of different peptides, finding that smaller nanoparticles inhibit while larger ones accelerate aggregation.

A short HBV RNA region induces RNR-R2 expression in non-cycling cells and in primary human hepatocytes

The paper identifies a 125-base RNA region in HBV transcripts that induces RNR-R2 expression in non-cycling cells and primary human hepatocytes without requiring HBx protein.

Oncogenic addiction to high 26S proteasome levels

This study shows cancer cells depend on high 26S proteasome levels for survival, and reducing 26S proteasome levels kills cancer cells while sparing normal cells.

NQO1 Binds And Supports SIRT1 Function

This study shows that SIRT1 regulates NQO1 expression and that NQO1 binds SIRT1 to mediate its protective role during mitochondrial stress.